HV2601 is a low charge injection 16-channel high voltage analog switch integrated circuit (IC) intended for use in applications requiring high voltage switching controlled by low voltage control signals, such as medical ultrasound imaging and other piezoelectric transducer drivers. Input data are shifted into a 16-bit shift register that can then be retained in a 16-bit latch. To reduce any possible clock feed-through noise, the latch enable bar should be left high until all bits are clocked in. Data are clocked in during the rising edge of the clock. Using HVCMOS technology, this device combines high voltage bilateral DMOS switches and low power CMOS logic to provide efficient control of high voltage analog signals. The device is suitable for various combinations of high voltage supplies, e.g., VPP/VNN: +40V/-160V, +100V/-100V, and +160V/-40V.